PNEI and Research Archivi - PNEI

Mag202025 by Redazione_PneiNo Comments

Neuroimmune Therapy for the Treatment of Cancer, Autoimmune, and Neurodegenerative Diseases

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Recent advances in psycho-neuro-endocrino-immunology suggest that many non-communicable diseases (NCD) originate from disruptions in the cytokine-based immune network (a complex system of communication and regulation among immune cells mediated by cytokines) leading to chronic inflammatory responses. This persistent low-grade inflammation is attributed to deficiencies in key endogenous anti-inflammatory neuroendocrine systems, including the pineal gland, the endocannabinoid system, and the angiotensin-converting enzyme 2 / angiotensin 1–7 axis. The administration of pineal methoxyindoles (melatonin, 5-methoxytryptamine), cannabinoids, and angiotensin 1–7 may offer potential therapeutic benefits for NCD, particularly in patients who are unresponsive to conventional treatments. From...

Mar162025 by Redazione_PneiNo Comments

The Fundamental Role of Oxytocin in The Treatment of Human Depression

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Recent advances in Psychoneuroendocrinoimmunology have suggested that the serotonin deficiency associated with depression is the simple consequence of an enhanced activity of indole-2,3-dioxygenase (IDO), which transforms tryptophan into kynurenine instead of serotonin. Moreover, kynurenine, in addition to its neurotoxic action, has been shown to play an immunosuppressive activity by activating regulatory T lymphocytes (T reg). IDO expression is stimulated by IL-17, whose brain production appears to be under the regulatory control of the ACE-ACE2 system. An increased expression of ACE over ACE2 allows enhanced production of angiotensin II (Ang II) instead of angiotensin 1-7 (Ang 1-7). Ang II stimulates IL-17 secretion from glial cells, and IL-17 promotes the release of other inflammatory ...

Ago112017 by Redazione_PneiNo Comments

How a baby’s sex may play a role in pregnant women’s immunity

PNEI and Research

Evidence shows that the sex of a baby is associated with pregnant women’s immune responses. (altro…)

Ago42017 by Redazione_PneiNo Comments

Conundrum: brain damage is not always damaging

PNEI and Research

A study of how the adult brain functions. Strokes are usually, but not always, debilitating. This is the case of an Argentinian woman who suffered multiple strokes which, in many ways, had no effect on her daily functioning. (altro…)

Lug262017 by Redazione_PneiNo Comments

Are we stardust?

PNEI and Research

Scientists have discovered a bizarre similarity between human cells and neutron stars. (altro…)

Lug172017 by Redazione_PneiNo Comments

Forever young

PNEI and Research

How eating less can slow the aging process: Recent research shows why calorie reduction in mice gave them longer and healthier lives. Multi-billion-dollar industries, with their moisturizers, only go skin deep. Aging occurs deeper, at cellular level. (altro…)

Lug102017 by Redazione_PneiNo Comments

Autophagy: What doesn’t kill you makes you stronger

PNEI and Research

Cellular recycling process linked to beneficial effects of enduring mild stress, which has a positive effect on people’s lives. Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that this cellular process, called autophagy (the key to extending lifespan), is also critical to the benefits of temporary stress. The study creates new avenues to pursue treatments for neurological disorders such as Huntington’s disease. (altro…)

Giu192017 by Redazione_PneiNo Comments

Cancer cells do not grow out of thin air

PNEI and Research

Cancer cells rely on the healthy cells that surround them for sustenance. They reroute blood vessels to nourish themselves, and secrete chemicals that scramble immune responses. (altro…)

Giu162017 by Redazione_PneiNo Comments

Married people have lower levels of cortisol

PNEI and Research

Research has found that married people are healthier than those who are single, divorced or widowed. Recent research at Carnegie Mellon University provides the first biological evidence to explain how marriage impacts health. (altro…)

Apr212017 by Redazione_PneiNo Comments

Scientist reveal a potential way of boosting the immune system

PNEI and Research

Breaking news from the Medical Research team at Southampton University, in the UK: Scientists, led by Professor Aymen Al.Shamkhani, have discovered a potential way of boosting the immune system’s memory to fight cancer. The answer would seem to lie in the AKt protein which acts as a catalyst on the function of the cytotoxic T cells. (altro…)