{"id":82,"date":"2017-07-10T10:42:48","date_gmt":"2017-07-10T08:42:48","guid":{"rendered":"https:\/\/www.pnei.it\/en\/?p=82"},"modified":"2021-02-06T15:18:00","modified_gmt":"2021-02-06T14:18:00","slug":"autophagy-doesnt-kill-makes-stronger","status":"publish","type":"post","link":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/","title":{"rendered":"Autophagy: What doesn\u2019t kill you makes you stronger"},"content":{"rendered":"
\"roundworms\"
Experiments carried out on round worms showed that their lifespan increased when subjected to bouts of mild heat shock.<\/figcaption><\/figure>\n

Cellular recycling process linked to beneficial effects of enduring mild stress, which has a positive effect on people\u2019s lives. <\/strong><\/em><\/p>\n

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that this cellular process, called autophagy (the key to extending lifespan), is also critical to the benefits of temporary stress.<\/strong> The study creates new avenues to pursue treatments for neurological disorders such as Huntington\u2019s disease.<\/span><\/p>\n

Autophagy is a means of recycling cells\u2019 old, broken, or unneeded parts<\/strong>, so that their components can be re-used to make new molecules or burned for energy; a process linked to longevity, at a cellular level.<\/span><\/p>\n

Roundworms and Autophagy<\/h2>\n

Experiments carried out on round worms showed that their lifespan increased when subjected to bouts of mild heat shock.<\/strong> The researchers also found that mild heat shock also reduced the number of protein aggregates. These protein aggregates are stressful for cells and the cause of Huntington\u2019s disease<\/a>: a fatal inherited disease cause by neuronal proteins that stick together as patients age, leading to degeneration throughout the brain.<\/span><\/p>\n

Applications<\/h3>\n

The results may also be relevant to Alzheimer\u2019s<\/a> and Parkinson\u2019s diseases, <\/a>which are also caused by proteins clumping together.<\/strong><\/p>\n

Many questions are raised here. For example, how does induction of autophagy by mild heat stress early on make cells better able to survive heat later?<\/strong><\/span><\/p>\n

This ongoing research is of vital importance in the search for adequate treatments for neuronal-protein caused diseases, and may well prove that \u2018What doesn\u2019t kill you\u2019 does actually and paradoxically \u2018make you stronger\u2019.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Cellular recycling process linked to beneficial effects of enduring mild stress, which has a positive effect on people\u2019s lives. Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found […]<\/p>\n","protected":false},"author":1,"featured_media":84,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[15,14,13,16,10,9],"yoast_head":"\nAutophagy: What doesn\u2019t kill you makes you stronger - PNEI - Eng<\/title>\n<meta name=\"description\" content=\"Autophagy is a cellular recycling process linked to beneficial effects of enduring mild stress and open new therapies ways\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Autophagy: What doesn\u2019t kill you makes you stronger - PNEI - Eng\" \/>\n<meta property=\"og:description\" content=\"Autophagy is a cellular recycling process linked to beneficial effects of enduring mild stress and open new therapies ways\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/\" \/>\n<meta property=\"og:site_name\" content=\"PNEI - Eng\" \/>\n<meta property=\"article:published_time\" content=\"2017-07-10T08:42:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-06T14:18:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pnei.it\/wp-content\/uploads\/sites\/2\/2017\/07\/roundworms.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Redazione_Pnei\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Redazione_Pnei\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/\"},\"author\":{\"name\":\"Redazione_Pnei\",\"@id\":\"https:\/\/www.pnei.it\/en\/#\/schema\/person\/6e1d9061e94bb0b181037f314f07708d\"},\"headline\":\"Autophagy: What doesn\u2019t kill you makes you stronger\",\"datePublished\":\"2017-07-10T08:42:48+00:00\",\"dateModified\":\"2021-02-06T14:18:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/\"},\"wordCount\":291,\"publisher\":{\"@id\":\"https:\/\/www.pnei.it\/en\/#organization\"},\"keywords\":[\"Alzheimer\",\"Huntington's disease\",\"neurons\",\"Parkinson\",\"PNEI\",\"stress\"],\"articleSection\":[\"PNEI and Research\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/\",\"url\":\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/\",\"name\":\"Autophagy: What doesn\u2019t kill you makes you stronger - PNEI - Eng\",\"isPartOf\":{\"@id\":\"https:\/\/www.pnei.it\/en\/#website\"},\"datePublished\":\"2017-07-10T08:42:48+00:00\",\"dateModified\":\"2021-02-06T14:18:00+00:00\",\"description\":\"Autophagy is a cellular recycling process linked to beneficial effects of enduring mild stress and open new therapies ways\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.pnei.it\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Autophagy: What doesn\u2019t kill you makes you stronger\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pnei.it\/en\/#website\",\"url\":\"https:\/\/www.pnei.it\/en\/\",\"name\":\"PNEI - Eng\",\"description\":\"International Institute of PNEI\",\"publisher\":{\"@id\":\"https:\/\/www.pnei.it\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pnei.it\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.pnei.it\/en\/#organization\",\"name\":\"PNEI - Eng\",\"url\":\"https:\/\/www.pnei.it\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/www.pnei.it\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.pnei.it\/wp-content\/uploads\/sites\/2\/2017\/04\/cropped-Logo-PNEI.png\",\"contentUrl\":\"https:\/\/www.pnei.it\/wp-content\/uploads\/sites\/2\/2017\/04\/cropped-Logo-PNEI.png\",\"width\":300,\"height\":60,\"caption\":\"PNEI - Eng\"},\"image\":{\"@id\":\"https:\/\/www.pnei.it\/en\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pnei.it\/en\/#\/schema\/person\/6e1d9061e94bb0b181037f314f07708d\",\"name\":\"Redazione_Pnei\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/www.pnei.it\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/fe081d69f91e30ffd70cdda2cf8f9cb6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/fe081d69f91e30ffd70cdda2cf8f9cb6?s=96&d=mm&r=g\",\"caption\":\"Redazione_Pnei\"},\"url\":\"https:\/\/www.pnei.it\/en\/author\/redazione_pnei\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Autophagy: What doesn\u2019t kill you makes you stronger - PNEI - Eng","description":"Autophagy is a cellular recycling process linked to beneficial effects of enduring mild stress and open new therapies ways","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/","og_locale":"it_IT","og_type":"article","og_title":"Autophagy: What doesn\u2019t kill you makes you stronger - PNEI - Eng","og_description":"Autophagy is a cellular recycling process linked to beneficial effects of enduring mild stress and open new therapies ways","og_url":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/","og_site_name":"PNEI - Eng","article_published_time":"2017-07-10T08:42:48+00:00","article_modified_time":"2021-02-06T14:18:00+00:00","og_image":[{"width":800,"height":500,"url":"https:\/\/www.pnei.it\/wp-content\/uploads\/sites\/2\/2017\/07\/roundworms.jpg","type":"image\/jpeg"}],"author":"Redazione_Pnei","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"Redazione_Pnei","Tempo di lettura stimato":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/#article","isPartOf":{"@id":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/"},"author":{"name":"Redazione_Pnei","@id":"https:\/\/www.pnei.it\/en\/#\/schema\/person\/6e1d9061e94bb0b181037f314f07708d"},"headline":"Autophagy: What doesn\u2019t kill you makes you stronger","datePublished":"2017-07-10T08:42:48+00:00","dateModified":"2021-02-06T14:18:00+00:00","mainEntityOfPage":{"@id":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/"},"wordCount":291,"publisher":{"@id":"https:\/\/www.pnei.it\/en\/#organization"},"keywords":["Alzheimer","Huntington's disease","neurons","Parkinson","PNEI","stress"],"articleSection":["PNEI and Research"],"inLanguage":"it-IT"},{"@type":"WebPage","@id":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/","url":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/","name":"Autophagy: What doesn\u2019t kill you makes you stronger - PNEI - Eng","isPartOf":{"@id":"https:\/\/www.pnei.it\/en\/#website"},"datePublished":"2017-07-10T08:42:48+00:00","dateModified":"2021-02-06T14:18:00+00:00","description":"Autophagy is a cellular recycling process linked to beneficial effects of enduring mild stress and open new therapies ways","breadcrumb":{"@id":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pnei.it\/en\/2017\/07\/10\/autophagy-doesnt-kill-makes-stronger\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.pnei.it\/en\/"},{"@type":"ListItem","position":2,"name":"Autophagy: What doesn\u2019t kill you makes you stronger"}]},{"@type":"WebSite","@id":"https:\/\/www.pnei.it\/en\/#website","url":"https:\/\/www.pnei.it\/en\/","name":"PNEI - Eng","description":"International Institute of PNEI","publisher":{"@id":"https:\/\/www.pnei.it\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pnei.it\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/www.pnei.it\/en\/#organization","name":"PNEI - Eng","url":"https:\/\/www.pnei.it\/en\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/www.pnei.it\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.pnei.it\/wp-content\/uploads\/sites\/2\/2017\/04\/cropped-Logo-PNEI.png","contentUrl":"https:\/\/www.pnei.it\/wp-content\/uploads\/sites\/2\/2017\/04\/cropped-Logo-PNEI.png","width":300,"height":60,"caption":"PNEI - Eng"},"image":{"@id":"https:\/\/www.pnei.it\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.pnei.it\/en\/#\/schema\/person\/6e1d9061e94bb0b181037f314f07708d","name":"Redazione_Pnei","image":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/www.pnei.it\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/fe081d69f91e30ffd70cdda2cf8f9cb6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fe081d69f91e30ffd70cdda2cf8f9cb6?s=96&d=mm&r=g","caption":"Redazione_Pnei"},"url":"https:\/\/www.pnei.it\/en\/author\/redazione_pnei\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/posts\/82"}],"collection":[{"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/comments?post=82"}],"version-history":[{"count":1,"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/posts\/82\/revisions"}],"predecessor-version":[{"id":85,"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/posts\/82\/revisions\/85"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/media\/84"}],"wp:attachment":[{"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/media?parent=82"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/categories?post=82"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pnei.it\/en\/wp-json\/wp\/v2\/tags?post=82"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}