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Cure with PNEI

Mag202025 by Redazione_PneiNo Comments
Neuroimmune Therapy for the Treatment of Cancer, Autoimmune, and Neurodegenerative Diseases

Neuroimmune Therapy for the Treatment of Cancer, Autoimmune, and Neurodegenerative Diseases

Cure with PNEI, PNEI and Research, Recommended for you, Senza categoria
Recent advances in psycho-neuro-endocrino-immunology suggest that many non-communicable diseases (NCD) originate from disruptions in the cytokine-based immune network (a complex system of communication and regulation among immune cells mediated by cytokines) leading to chronic inflammatory responses. This persistent low-grade inflammation is attributed to deficiencies in key endogenous anti-inflammatory neuroendocrine systems, including the pineal gland, the endocannabinoid system, and the angiotensin-converting enzyme 2 / angiotensin 1–7 axis. The administration of pineal methoxyindoles (melatonin, 5-methoxytryptamine), cannabinoids, and angiotensin 1–7 may offer potential therapeutic benefits for NCD, particularly in patients who are unresponsive to conventional treatments. From...
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Mar162025 by Redazione_PneiNo Comments
The Fundamental Role of Oxytocin in The Treatment of Human Depression

The Fundamental Role of Oxytocin in The Treatment of Human Depression

Cure with PNEI, PNEI and Research
Recent advances in Psychoneuroendocrinoimmunology have suggested that the serotonin deficiency associated with depression is the simple consequence of an enhanced activity of indole-2,3-dioxygenase (IDO), which transforms tryptophan into kynurenine instead of serotonin. Moreover, kynurenine, in addition to its neurotoxic action, has been shown to play an immunosuppressive activity by activating regulatory T lymphocytes (T reg). IDO expression is stimulated by IL-17, whose brain production appears to be under the regulatory control of the ACE-ACE2 system. An increased expression of ACE over ACE2 allows enhanced production of angiotensin II (Ang II) instead of angiotensin 1-7 (Ang 1-7). Ang II stimulates IL-17 secretion from glial cells, and IL-17 promotes the release of other inflammatory ...
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